Elevated blood glucose due to critical illness ("stress hyperglycemia") is seen in most intensive care unit patients. The elevated blood glucose has detrimental effects on the body through several different mechanisms. Clinicians must balance the risks of stress hyperglycemia versus the risk of dangerous low blood glucose values ("hypoglycemia").
The large NICE-SUGAR study showed that normalizing blood glucose is not safe with the current technology. Most ICUs that focus on blood glucose control either use inaccurate point-of-care glucometers or accurate and infrequent or time-consuming blood gas analyses.
GlucoSet's sensors is unique because of it delivers high accuracy, rapid measurements and high sensitivity in the hypoglycemic range. GlucoSet is focused on developing products that fit into the existing workflow of nurses and physicians, maximizing the acceptance of new technology.
Several studies have shown mortality is higher for intensive care unit patients that have blood glucose levels outside of the normal range (80-110 mg/dl), and this effect is strongest in non-diabetic patients (figure below from Kosiborod et al.).
Normalizing the blood glucose reduces the risk of renal failure and sepsis, a very dangerous condition for Intensive Care Unit patients. As with mortality, the risk reduction is larger for non-diabetic patients.
A single case of sepsis on average costs hospitals over $20 000 and the average cost per day of stay is $1 500 in direct costs for the hospital. A reduction in the incidence of sepsis and length of stay thus has a direct impact on costs.
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